kdps - Kinship Decouple and Phenotype Selection (KDPS)

A phenotype-aware algorithm for resolving cryptic relatedness in genetic studies. It removes related individuals based on kinship or identity-by-descent (IBD) scores while prioritizing subjects with phenotypes of interest. This approach helps maximize the retention of informative subjects, particularly for rare or valuable traits, and improves statistical power in genetic and epidemiological studies. KDPS supports both categorical and quantitative phenotypes, composite scoring, and customizable pruning strategies using a fuzziness parameter. Benchmark results show improved phenotype retention and high computational efficiency on large-scale datasets like the UK Biobank. Methods used include Manichaikul et al. (2010) <doi:10.1093/bioinformatics/btq559> for kinship estimation, Purcell et al. (2007) <doi:10.1086/519795> for IBD estimation, and Bycroft et al. (2018) <doi:10.1038/s41586-018-0579-z> for UK Biobank data reference.

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3.70 score 163 downloads

bolt4jr - Interface for the 'Neo4j Bolt' Protocol

Querying, extracting, and processing large-scale network data from Neo4j databases using the 'Neo4j Bolt' <https://neo4j.com/docs/bolt/current/bolt/> protocol. This interface supports efficient data retrieval, batch processing for large datasets, and seamless conversion of query results into R data frames, making it ideal for bioinformatics, computational biology, and other graph-based applications.

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3.70 score 2 scripts 221 downloads

gptr - A Convenient R Interface with the OpenAI 'ChatGPT' API

A convenient interface with the OpenAI 'ChatGPT' API <https://openai.com/api>. 'gptr' allows you to interact with 'ChatGPT', a powerful language model, for various natural language processing tasks. The 'gptr' R package makes talking to 'ChatGPT' in R super easy. It helps researchers and data folks by simplifying the complicated stuff, like asking questions and getting answers. With 'gptr', you can use 'ChatGPT' in R without any hassle, making it simpler for everyone to do cool things with language!

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3.00 score 2 stars 6 scripts 207 downloads

ggmugs - Visualization of Multiple Genome-Wide Association Study Summary Statistics

A 'grammar of graphics' approach for visualizing summary statistics from multiple Genome-wide Association Studies (GWAS). It offers geneticists, bioinformaticians, and researchers a powerful yet flexible tool for illustrating complex genetic associations using data from various GWAS datasets. The visualizations can be extensively customized, facilitating detailed comparative analysis across different genetic studies. Reference: Uffelmann, E. et al. (2021) <doi:10.1038/s43586-021-00056-9>.

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2.70 score 2 scripts 637 downloads